Title : A novel transduction mechanism mediating dopamine-induced vascular relaxation: opening of BKCa channels by cyclic AMP-induced stimulation of the cyclic GMP-dependent protein kinase.

Pub. Date : 1999 Nov

PMID : 10547076






1 Functional Relationships(s)
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1 These findings demonstrate that activation of DA-1 receptors causes stimulation of BKCa channel activity by a mechanism involving cyclic AMP-dependent stimulation of PKG, but not PKA, and further suggest that this cross-reactivity mediates dopamine-induced coronary vasodilation. Cyclic AMP protein kinase cGMP-dependent 1 Homo sapiens