Pub. Date : 1999 Oct
PMID : 10546924
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam. | Mibefradil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | BACKGROUND: The calcium channel blockers mibefradil and isradipine inhibit CYP3A4 in vitro. | Mibefradil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CONCLUSION: Mibefradil but not isradipine markedly increases the plasma concentrations of triazolam and thereby enhances and prolongs its pharmacodynamic effects, consistent with potent inhibition of CYP3A4. | Mibefradil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |