Pub. Date : 1999 Nov 1
PMID : 10545114
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | p53 induced ROS generation, which then caused a transient increase of Deltapsi followed by a decrease. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Thus, the ROS-mediated disruption of Deltapsi constitutes a pivotal step in the apoptotic pathway of p53, and this pathway does not involve cytochrome c release. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |