Pub. Date : 1999 Sep
PMID : 10543438
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct. | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |
| 2 | Human calcitonin gene-related peptide (h-CGRP; 0.1 microM) mimicked the effect of capsaicin on resting preparations (contractile response =28% of KCl 80 mM). | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |
| 3 | h-CGRP (8-37) (1.5 microM) almost completely reversed the relaxations produced by both capsaicin and h-CGRP. | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |
| 4 | In vivo pretreatment with capsaicin (50 mg/kg; 6-7 days before) decreased the number of CGRP-IR nerves, whereas the TK-IR neural network was apparently unchanged. | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |
| 5 | In conclusion, our data provide functional evidence for the presence of capsaicin-sensitive primary afferent nerve endings in the guinea-pig terminal biliary tract, whose stimulation by capsaicin or EFS produces the release of tachykinins and CGRP. | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |
| 6 | In conclusion, our data provide functional evidence for the presence of capsaicin-sensitive primary afferent nerve endings in the guinea-pig terminal biliary tract, whose stimulation by capsaicin or EFS produces the release of tachykinins and CGRP. | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |
| 7 | The contractile response to capsaicin obtained in the presence of the three tachykinin receptor antagonists could be due to the co-released CGRP and/or to other unknown neurotransmitters. | Capsaicin | calcitonin related polypeptide alpha | Homo sapiens |