Title : Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2.

Pub. Date : 1999 Oct 29

PMID : 10531359






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The direct PKA activator, Bt(2)cAMP, caused concentration-dependent NO release and iNOS expression, as confirmed by immunofluorescence studies. Cyclic AMP nitric oxide synthase 2 Homo sapiens
2 Two cAMP-elevating agents, forskolin and cholera toxin, potentiated the LPS-induced NO release and iNOS expression. Cyclic AMP nitric oxide synthase 2 Homo sapiens
3 These results suggest that 6 h of treatment with LPS increases intracellular cAMP levels via COX-2 induction and prostaglandin E(2) production, resulting in PKA activation, NF-kappaB activation, iNOS expression, and NO production. Cyclic AMP nitric oxide synthase 2 Homo sapiens