Title : Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism.

Pub. Date : 1999 Nov

PMID : 10525096






1 Functional Relationships(s)
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1 The selectivity of ketoconazole, a chemical inhibitor of CYP3A4, was probed with mAb(3A4a) and was shown to be highly concentration dependent in the diazepam N-demethylation by human liver microsomes. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens