Title : Phorbol ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways.

Pub. Date : 1999 Oct 14

PMID : 10523856






2 Functional Relationships(s)
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1 TPA also activated the Raf1/MEK/ERK cascade and activated another MAPK member, p38, but not JNK. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens
2 These data demonstrate that MDR1 induction by TPA occurs via a PKC-dependent mechanism that operates independently of ERK, p38 or JNK pathways, and thus have important implications for understanding the mechanisms of MDR1 induction by extracellular stimuli. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 14 Homo sapiens