Title : Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms.

Pub. Date : 1999 Sep

PMID : 10510443






2 Functional Relationships(s)
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1 Cyclosporin A, but not FK506, suppressed expression of mRNA for NOS2 in a concentration-dependent manner when co-incubated with LPS. Cyclosporine nitric oxide synthase 2, inducible Mus musculus
2 Cyclosporin A suppresses NOS2 gene transcription, but FK506 acts post-transcriptionally to suppress NO generation in VSMC. Cyclosporine nitric oxide synthase 2, inducible Mus musculus