Title : Potencies of haloperidol metabolites as inhibitors of the human noradrenaline, dopamine and serotonin transporters in transfected COS-7 cells.

Pub. Date : 1999 Aug

PMID : 10494878






2 Functional Relationships(s)
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1 In this study, the hypothesis was partially investigated by determining the potencies of haloperidol and reduced haloperidol and the corresponding pyridinium and tetrahydropyridine metabolites, compared with MPP+ and MPTP, as inhibitors of the noradrenaline transporter (NAT), dopamine transporter (DAT) and 5-HT transporter (SERT). Haloperidol solute carrier family 6 member 3 Homo sapiens
2 Haloperidol, its five metabolites and MPP+ and MPTP all inhibited NAT, DAT and SERT. Haloperidol solute carrier family 6 member 3 Homo sapiens