Title : Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are more sensitive to carbamazepine.

Pub. Date : 1999 Sep

PMID : 10487182






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: ACh-evoked currents at the human alpha4beta2 nAChR were readily and reversibly inhibited by approximately 100 microM CBZ. Carbamazepine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens
2 The increased sensitivity of these mutant receptors supports the hypothesis that the antiepileptic activity of CBZ can, at least to some extent, be attributed to the nAChR inhibition. Carbamazepine cholinergic receptor nicotinic alpha 4 subunit Homo sapiens