Pub. Date : 1999 Sep
PMID : 10482990
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Idarubicin DNA intercalation is reduced by MRP1 and not Pgp. | Idarubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 2 | Currently available data regarding the substrate specificity of the multi-drug resistance (MDR) mechanisms P-glycoprotein (Pgp) and MDR-associated protein (MRP1) for idarubicin are inconclusive. | Idarubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 3 | The data demonstrate that daunorubicin DNA intercalation is affected by both Pgp and MRP1 whereas idarubicin DNA intercalation is affected only by MRP1. | Idarubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |