Title : MDR1 gene expression in normal and atherosclerotic human arteries(1).

Pub. Date : 1999 Jul-Aug

PMID : 10474039






5 Functional Relationships(s)
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1 Recent studies have shown that a membrane p-glycoprotein, encoded by MDR1 gene, is involved in the transport of free cholesterol from the plasma membrane to endoplasmic reticulum, the site of cholesterol esterification by acyl-CoA:cholesterol acyltransferase (ACAT). Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
2 Recent studies have shown that a membrane p-glycoprotein, encoded by MDR1 gene, is involved in the transport of free cholesterol from the plasma membrane to endoplasmic reticulum, the site of cholesterol esterification by acyl-CoA:cholesterol acyltransferase (ACAT). Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
3 Recent studies have shown that a membrane p-glycoprotein, encoded by MDR1 gene, is involved in the transport of free cholesterol from the plasma membrane to endoplasmic reticulum, the site of cholesterol esterification by acyl-CoA:cholesterol acyltransferase (ACAT). Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
4 Recent studies have shown that a membrane p-glycoprotein, encoded by MDR1 gene, is involved in the transport of free cholesterol from the plasma membrane to endoplasmic reticulum, the site of cholesterol esterification by acyl-CoA:cholesterol acyltransferase (ACAT). Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens
5 In this study, lipid content and the expression of the genes involved in cholesterol metabolism such as hydroxy-methylglutaryl coenzyme A reductase (HMGCoA-R), low-density lipoprotein receptor (LDL-R), ACAT and MDR1 have been investigated in control and atherosclerotic arteries. Cholesterol ATP binding cassette subfamily B member 1 Homo sapiens