Pub. Date : 1999 Sep
PMID : 10470083
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In our study of alternative or additional mechanisms of resistance operating during antiviral therapy, overexpression and amplification of the MRP4 gene correlated with ATP-dependent efflux of PMEA (9-(2-phosphonylmethoxyethyl)adenine) and azidothymidine monophosphate from cells and, thus, with resistance to these drugs. | adefovir | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 2 | In our study of alternative or additional mechanisms of resistance operating during antiviral therapy, overexpression and amplification of the MRP4 gene correlated with ATP-dependent efflux of PMEA (9-(2-phosphonylmethoxyethyl)adenine) and azidothymidine monophosphate from cells and, thus, with resistance to these drugs. | adefovir | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 3 | Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs. | adefovir | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 4 | Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs. | adefovir | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 5 | Increased resistance to PMEA and amplification of the MRP4 gene correlated with enhanced drug efflux; transfer of chromosome 13 containing the amplified MRP4 gene conferred resistance to PMEA. | adefovir | ATP binding cassette subfamily C member 4 | Homo sapiens |