Title : Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6.

Pub. Date : 1999 Sep

PMID : 10460810






1 Functional Relationships(s)
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1 No remarkable inhibition of other CYP isoforms was observed except for moderate inhibition of CYP1A2-catalyzed phenacetin O-deethylation by fluphenazine (K(i) = 40.2 microM) and perphenazine (K(i) = 65.1). Phenacetin cytochrome P450 family 1 subfamily A member 2 Homo sapiens