Title : Evidence that the apoptotic actions of etoposide are independent of c-Jun/activating protein-1-mediated transregulation.

Pub. Date : 1999 Sep

PMID : 10454518






2 Functional Relationships(s)
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1 Induction of apoptotic cell death and DNA damage by treatment of U937 cells with etoposide (100 microM) was associated with phosphorylation and activation of the c-Jun NH(2)-terminal kinase (JNK1) SAPK enzymes p46 and p54-JNK2 and transient increases in expression of the transcription factor c-Jun, a primary JNK substrate. Etoposide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Induction of apoptotic cell death and DNA damage by treatment of U937 cells with etoposide (100 microM) was associated with phosphorylation and activation of the c-Jun NH(2)-terminal kinase (JNK1) SAPK enzymes p46 and p54-JNK2 and transient increases in expression of the transcription factor c-Jun, a primary JNK substrate. Etoposide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens