Title : Expression of the 11beta-hydroxysteroid dehydrogenase types 1 and 2 proteins in human and baboon placental syncytiotrophoblast.

Pub. Date : 1999 Sep

PMID : 10452912






1 Functional Relationships(s)
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1 Because 11beta-HSD-1 can function as a reductase, the expression of 11beta-HSD-1 in human syncytiotrophoblast would be consistent with the ability of this tissue to convert cortisone to cortisol and provide a means by which transplacental transport of cortisol could regulate the fetal pituitary adrenocortical axis in the human, as recently shown experimentally in the non-human primate baboon model. Hydrocortisone hydroxysteroid 11-beta dehydrogenase 1 Homo sapiens