Title : Common conformational effects in the p53 protein of vinyl chloride-induced mutations.

Pub. Date : 1999 May

PMID : 10449043






3 Functional Relationships(s)
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1 In order to determine whether these conformational changes are consistent for other p53 mutants, we have now used molecular dynamics to determine the structure of the DNA-binding core domain of the Leu 179 p53 mutant. Leucine tumor protein p53 Homo sapiens
2 In order to determine whether these conformational changes are consistent for other p53 mutants, we have now used molecular dynamics to determine the structure of the DNA-binding core domain of the Leu 179 p53 mutant. Leucine tumor protein p53 Homo sapiens
3 The results indicate that the Leu 179 mutant differs substantially from the wild-type structure in certain discrete regions that are similar to those noted previously in the other p53 mutants. Leucine tumor protein p53 Homo sapiens