Pub. Date : 1999 Aug
PMID : 10444521
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Immunotargeting of glucose oxidase: intracellular production of H(2)O(2) and endothelial oxidative stress. | Hydrogen Peroxide | hydroxyacid oxidase 1 | Homo sapiens |
| 2 | Both H(2)O(2) added exogenously to the cell medium (extracellular H(2)O(2)) and that generated by anti-PECAM-GOX caused oxidative stress manifested by time- and dose-dependent irreversible plasma membrane damage. | Hydrogen Peroxide | hydroxyacid oxidase 1 | Homo sapiens |
| 3 | Therefore, treatment of PECAM-positive cells with anti-PECAM-GOX leads to conjugate internalization, predominantly intracellular H(2)O(2) generation and intracellular oxidative stress. | Hydrogen Peroxide | hydroxyacid oxidase 1 | Homo sapiens |