Title : Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity.

Pub. Date : 1999 Aug

PMID : 10444519






3 Functional Relationships(s)
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1 TNF-alpha and IL-1beta decreased the uptake of TBI; however, the uptake of NTBI was increased. Thioacetazone tumor necrosis factor Homo sapiens
2 Coexposure to TNF-alpha and NTBI, but not to TBI, induced MDA accumulation and greater cytotoxicity (MTT and lactate dehydrogenase release) than TNF-alpha alone. Thioacetazone tumor necrosis factor Homo sapiens
3 These findings indicate that TNF-alpha and IL-1beta modulate iron uptake by A549 cells, with differing effects on TBI and NTBI, as well as on H-ferritin synthesis. Thioacetazone tumor necrosis factor Homo sapiens