Title : Mechanisms of MAPK activation by bradykinin in vascular smooth muscle cells.

Pub. Date : 1999 Aug

PMID : 10444401






3 Functional Relationships(s)
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Protein Name
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1 Addition of 10(-10)-10(-7) M BK to VSMC resulted in a rapid and concentration-dependent increase in tyrosine phosphorylation of several 144- to 40-kDa proteins. Tyrosine kininogen 1 Homo sapiens
2 Immunoprecipitation with anti-phosphotyrosine antibodies followed by immunoblot revealed that 10(-9) M BK induced tyrosine phosphorylation of focal adhesion kinase (p125(FAK)). Tyrosine kininogen 1 Homo sapiens
3 Protein kinase C downregulation by phorbol 12-myristate 13-acetate and/or inhibitors to protein kinase C, p60(src) kinase, and MAPK kinase inhibited BK-induced MAPK tyrosine phosphorylation. Tyrosine kininogen 1 Homo sapiens