Pub. Date : 1999 Jul
PMID : 10430059
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We sought to determine whether the increase of the message of the "growth arrest and DNA damage-inducible" gene, GADD153, could be used to assess the extent of the cellular injury response in model systems and in patients with head and neck cancer after treatment with cDDP. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | The mRNA levels of GADD153, a gene highly transcriptionally activated by cDDP damage, were increased in a transient, concentration-dependent manner by cDDP when human UMSCC10b head and neck carcinoma cells were treated with cDDP both in vitro and when grown as tumor xenografts in nude mice. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | GADD153 mRNA levels were measured in biopsies obtained before and 24 h after treatment with cDDP from 32 patients with stage III/IV head and neck cancer. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | We conclude that the magnitude of the increase in GADD153 mRNA is a promising candidate for service as an intermediate marker of head and neck tumor response to cDDP. | Cisplatin | DNA damage inducible transcript 3 | Homo sapiens |