Title : Losartan-sensitive renal damage caused by chronic NOS inhibition does not involve increased renal angiotensin II concentrations.

Pub. Date : 1999 Jul

PMID : 10411696






2 Functional Relationships(s)
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1 L-NNA treatment during four days resulted in a significant decrease in renal Ang II (183 +/- 32 vs. 454 +/- 40 fmol/g in control, P < 0.05). Nitroarginine angiotensinogen Rattus norvegicus
2 Blood Ang II was not significantly different from the control on days 4, 7, and 14 but was significantly increased after 21 days of L-NNA treatment (215 +/- 35 vs. 78 +/- 13 fmol/ml in control, P < 0.05). Nitroarginine angiotensinogen Rattus norvegicus