Title : 9-cis-retinoic acid decreases the level of its cognate receptor, retinoid X receptor, through acceleration of the turnover.

Pub. Date : 1999 Jul 14

PMID : 10403834






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Western blot analysis revealed that a treatment with 1 microM 9-cis-retinoic acid (9-cis RA) for 24 h decreased RXRalpha protein level to 72 +/- 9 and 75 +/- 7% in HepG2 and JEG-3 cells, respectively, when the levels in the non-treated cells were expressed as 100%. Radium retinoid X receptor alpha Homo sapiens
2 It was thus demonstrated that 9-cis RA downregulates RXRalpha by increasing the turnover of the protein in the two cell lines. Radium retinoid X receptor alpha Homo sapiens