Title : Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function.

Pub. Date : 1999 Aug

PMID : 10403730






2 Functional Relationships(s)
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1 RESULTS: Relative to controls, significant changes (p<0.05) occurred in cells incubated with IFN-gamma for two days: TER was decreased to 20 (6.2)%, FITC-dextran flux was increased by 109 (19)-fold, cAMP and Ca dependent I(sc) were decreased to 51 (6.4)% and 24 (2.2)%, respectively, and CFTR levels were decreased to 47 (11)%. Cyclic AMP interferon gamma Homo sapiens
2 Relative to controls, significant changes occurred after one day of culture with IFN-gamma plus TNF-alpha: TER was decreased to 27 (3.5)%, FITC-dextran flux was increased by 185 (45)-fold, and cAMP and Ca dependent I(sc) were decreased to 66 (12)% and 35 (6.8)%, respectively. Cyclic AMP interferon gamma Homo sapiens