Title : Inductive and inhibitory effects of non-ortho-substituted polychlorinated biphenyls on estrogen metabolism and human cytochromes P450 1A1 and 1B1.

Pub. Date : 1999 Jul 1

PMID : 10403516






1 Functional Relationships(s)
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1 Exposure of MCF-7 cells to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated levels of the CYP1A1 and CYP1B1 mRNAs, but did not cause elevated rates of E2 metabolism; rather, 4-MeOE2 production was depressed to below control levels in PCB 169-treated cultures. 3,4,5,3',4',5'-hexachlorobiphenyl cytochrome P450 family 1 subfamily A member 1 Homo sapiens