Pub. Date : 1999 Jul 1
PMID : 10403516
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inductive and inhibitory effects of non-ortho-substituted polychlorinated biphenyls on estrogen metabolism and human cytochromes P450 1A1 and 1B1. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | The effects of a series of non-ortho-substituted polychlorinated biphenyls (PCBs) on human cytochrome P450 1A1 (CYP1A1), a 17beta-estradiol (E2) 2-hydroxylase, and P450 1B1 (CYP1B1), an E2 4-hydroxylase, were investigated in HepG2 and MCF-7 cells. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Elevated rates of 2- and 4-methoxyestradiol (2- and 4-MeOE2) formation in PCB-treated cultures were measured as activities of CYP1A1 and CYP1B1, respectively. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Northern blot analyses confirmed that exposure of MCF-7 cells to PCBs 81, 126, and 39 caused highly elevated levels of the CYP1A1 and CYP1B1 mRNAs. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Exposure of MCF-7 cells to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated levels of the CYP1A1 and CYP1B1 mRNAs, but did not cause elevated rates of E2 metabolism; rather, 4-MeOE2 production was depressed to below control levels in PCB 169-treated cultures. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 6 | These studies with one subgroup of PCBs, the non-ortho-substituted congeners, underscore the complexity and diversity of effects of PCBs, as individual congeners were found both to induce expression and to inhibit activity of human CYP1B1 and CYP1A1. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |