Pub. Date : 1999 Jul 1
PMID : 10403516
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Elevated rates of 2- and 4-methoxyestradiol (2- and 4-MeOE2) formation in PCB-treated cultures were measured as activities of CYP1A1 and CYP1B1, respectively. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | Northern blot analyses confirmed that exposure of MCF-7 cells to PCBs 81, 126, and 39 caused highly elevated levels of the CYP1A1 and CYP1B1 mRNAs. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | Exposure of MCF-7 cells to 3,3",4,4",5,5"-hexachlorobiphenyl (PCB 169) resulted in elevated levels of the CYP1A1 and CYP1B1 mRNAs, but did not cause elevated rates of E2 metabolism; rather, 4-MeOE2 production was depressed to below control levels in PCB 169-treated cultures. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 4 | In microsomal assays, inhibition of cDNA-expressed human CYP1B1 by PCBs 169 and 126 was demonstrated. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 5 | These studies with one subgroup of PCBs, the non-ortho-substituted congeners, underscore the complexity and diversity of effects of PCBs, as individual congeners were found both to induce expression and to inhibit activity of human CYP1B1 and CYP1A1. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 6 | These studies with one subgroup of PCBs, the non-ortho-substituted congeners, underscore the complexity and diversity of effects of PCBs, as individual congeners were found both to induce expression and to inhibit activity of human CYP1B1 and CYP1A1. | Polychlorinated Biphenyls | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |