Pub. Date : 1999 Jul 16
PMID : 10400652
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of macrophages with vanadate results in the activation of both NF-kappaB and c-Jun N-terminal kinase (JNK). | Vanadates | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Treatment of macrophages with vanadate results in the activation of both NF-kappaB and c-Jun N-terminal kinase (JNK). | Vanadates | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Conversely, blockage of JNK activation by transfection of a kinase-inactive form of SEK1 resulted in partially inhibition of vanadate-induced IkappaBalpha degradation. | Vanadates | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Both vanadate-induced degradation of IkappaBalpha and activation of JNK were potently inhibited by pretreatment of cells with N-acetylcysteine or dimercaprol. | Vanadates | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | These results demonstrate that early activation of stress kinases or change of cellular redox states plays a key role in vanadate-induced activation of NF-kappaB and JNK. | Vanadates | mitogen-activated protein kinase 8 | Homo sapiens |