Title : Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells.

Pub. Date : 1998 Dec

PMID : 10395202






1 Functional Relationships(s)
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1 Previous studies by our lab and others established that co-crosslinking sIg and IgG receptor FcgammaRIIb in B cells in a feedback suppression model (negative signaling) promoted tyrosine phosphorylation of the inositol 5-phosphatase SHIP and its interaction with Shc and that these events were associated with inhibition of the Ras pathway. Inositol inositol polyphosphate-5-phosphatase D Homo sapiens