Title : Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.

Pub. Date : 1999 Jun 24

PMID : 10391687






1 Functional Relationships(s)
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1 Thus, O6mG adducts account for the carcinogenic effect of MNU and MGMT overexpression is selectively able to reduce O6methylguanine adducts below a carcinogenic threshold. O-(6)-methylguanine O-6-methylguanine-DNA methyltransferase Mus musculus