Title : The influence of indomethacin on the metabolism and cytokine secretion of human aneurysmal aorta.

Pub. Date : 1999 Jul

PMID : 10388637






2 Functional Relationships(s)
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1 Indomethacin also reduced the release of interleukin-1beta (IL-1beta) (from 166 pg/ml to 9.8 pg/ml, p =0.04, n=5) and interleukin-6 (IL-6) (from 119 ng/ml to 57 ng/ml, p=0.028, n=6), but had no effect on monocyte chemotactic protein 1 or matrix metalloproteinase-9 secretion. Indomethacin interleukin 6 Homo sapiens
2 Indomethacin reduces the production of PGE2, IL-1beta and IL-6, suggesting that cyclo-oxygenase-2 inhibitors may control the inflammation in the aneurysm wall and potentially limit AAA growth. Indomethacin interleukin 6 Homo sapiens