Title : Thiol depletion induces apoptosis in cultured lung fibroblasts.

Pub. Date : 1999 Jul

PMID : 10385593






1 Functional Relationships(s)
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1 LT production and p38-MAPK phosphorylation were required for induction of apoptosis because thiol depletion-induced apoptosis was completely blocked by the 5-lipoxygenase inhibitor AA861, the LT antagonists FPL55712 and ONO1078, and the p38-MAPK inhibitor SB203580. FPL 55712 arachidonate 5-lipoxygenase Homo sapiens