Title : Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.

Pub. Date : 1999 Apr

PMID : 10385214






1 Functional Relationships(s)
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1 In microsomes from 12 livers from man the rate of N-debutylation of halofantrine correlated strongly with CYP 3A4 relative levels (P = 0.002) and less strongly, but significantly, with CYP 2C8 levels (P = 0.025). Nitrogen cytochrome P450 family 4 subfamily F member 3 Homo sapiens