Title : Pretransplant chemotherapy reduces inflammatory cytokine production and acute graft-versus-host disease after allogeneic bone marrow transplantation.

Pub. Date : 1999 Jun 15

PMID : 10385089






2 Functional Relationships(s)
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1 RESULTS: Three weeks after a single dose of cyclophosphamide, bone marrow and splenic cellularity was reduced by 50% and the production of TNF-alpha to LPS stimulation by macrophages was also markedly impaired (both before and after total body irradiation). Cyclophosphamide tumor necrosis factor Homo sapiens
2 This reduction occurred despite equivalent serum levels of lipopolysaccharide, consistent with the reductions in TNF-alpha and interleukin-1beta production by host macrophages after cyclophosphamide pretreatment. Cyclophosphamide tumor necrosis factor Homo sapiens