Title : Induction of cyclooxygenase-2 on activated T lymphocytes: regulation of T cell activation by cyclooxygenase-2 inhibitors.

Pub. Date : 1999 Jul 1

PMID : 10384106






1 Functional Relationships(s)
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1 Interestingly, treatment with COX-2-specific inhibitors such as NS398 or Celecoxib severely diminished early and late events of T cell activation, including CD25 and CD71 cell surface expression, IL-2, TNF-alpha, and IFN-gamma production and cell proliferation, but not the expression of CD69, an immediate early gene. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens