Title : Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes.

Pub. Date : 1999 Jul

PMID : 10383922






2 Functional Relationships(s)
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Protein Name
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1 Azelastine, desmethylazelastine, and 6-hydroxyazelastine competitively inhibited CYP2C9 activity (Ki = 13. azelastine cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 The inhibition of CYP2C9, CYP2C19, and CYP3A4 activity by azelastine and its two metabolites might be clinically insignificant. azelastine cytochrome P450 family 2 subfamily C member 9 Homo sapiens