Title : Selective inhibition of apoptosis by TPA-induced differentiation of U937 leukemic cells.

Pub. Date : 1999 Apr

PMID : 10381626






1 Functional Relationships(s)
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1 Exposure of undifferentiated U937 cells to 50 microM etoposide for 6 h, that triggers apoptosis in 80% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Mcl-1 expression without modifying Bcl-2, Bcl-xL and Bax protein levels. Etoposide cytochrome c, somatic Homo sapiens