Title : Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes.

Pub. Date : 1999 Jun

PMID : 10381057






4 Functional Relationships(s)
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1 Dexamethasone inhibited COX-2 mRNA expression induced by IL-1. Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Dexamethasone was the strongest drug inhibitor of COX-2 (IC50 = 0.0073 microM). Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12). Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12). Dexamethasone mitochondrially encoded cytochrome c oxidase II Homo sapiens