Title : Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.

Pub. Date : 1999 Jun 22

PMID : 10377455






1 Functional Relationships(s)
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1 These comparisons of the actions of >40 NSAIDs and novel COX-2-selective agents, including celecoxib, rofecoxib and diisopropyl fluorophosphate, demonstrate a distribution of compound selectivities toward COX-1 that aligns with the risk of serious gastrointestinal complications. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens