Pub. Date : 1999 Apr 1
PMID : 10374839
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In vitro experiments using human cell line cells and aflatoxin B1 have demonstrated the induction of p53 mutations in codon 249 and adjacent codons. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |
2 | In an in vivo rodent model systems using the aflatoxin B1-sensitive male F344 rat, previous studies have shown that hepatocarcinogenesis is accompanied by significant incidences of codon 12 mutations in K-ras and codon 13 mutations in N-ras genes, but in contrast to the human, apparently not by mutations in codon 243 of the p53 gene (which corresponds to codon 249 in the human gene). | Aflatoxin B1 | tumor protein p53 | Homo sapiens |