Title : Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase.

Pub. Date : 1999 Jul

PMID : 10373549






4 Functional Relationships(s)
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1 In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway. Cyclic AMP protein tyrosine kinase 2 beta Homo sapiens
2 In this report, we show that PKB can also be activated by PKA (cyclic AMP [cAMP]-dependent protein kinase) through a PI3-kinase-independent pathway. Cyclic AMP protein tyrosine kinase 2 beta Homo sapiens
3 Moreover, phosphopeptide maps of overexpressed PKB from COS cells showed differences between insulin- and forskolin-stimulated cells that pointed to distinct activation mechanisms of PKB depending on whether insulin or cAMP was used. Cyclic AMP protein tyrosine kinase 2 beta Homo sapiens
4 Moreover, phosphopeptide maps of overexpressed PKB from COS cells showed differences between insulin- and forskolin-stimulated cells that pointed to distinct activation mechanisms of PKB depending on whether insulin or cAMP was used. Cyclic AMP protein tyrosine kinase 2 beta Homo sapiens