Pub. Date : 1999 Jul
PMID : 10373510
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The full-length versions of the Ras-specific exchange factors Ras-GRF1 (GRF1) and Ras-GRF2 (GRF2), which are expressed in brain and a restricted number of other organs, possess an ionomycin-dependent activation of Erk mitogen-activated protein kinase activity in 293T cells (C. L. Farnsworth et al., Nature 376:524-527, 1995; N. P. Fam et al., Mol. | Ionomycin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Both mutants were impaired in their ability to mediate ionomycin-dependent Erk activity in 293T cells. | Ionomycin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | In the absence of ionomycin, 293T cells expressing wild-type GRF1 contained much higher levels of Ras-GTP than control cells; the increase in Erk activity induced by ionomycin in the GRF1-expressing cells also induced a concomitant increase in Raf kinase activity, but without a further increase in the level Ras-GTP. | Ionomycin | mitogen-activated protein kinase 1 | Homo sapiens |