Pub. Date : 1999 Jun
PMID : 10365914
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Mus musculus |
2 | HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Mus musculus |
3 | HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Mus musculus |
4 | HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Mus musculus |
5 | Analysis of the IGF-1 receptor (IGF-1r) and epidermal growth factor (EGFr) in the epidermis of TPA-treated HK1.IGF-1 transgenic and non-transgenic mice revealed that both receptors were activated (hyperphosphorylated on tyrosine residues), and the level of activation was higher in transgenic mice. | Tetradecanoylphorbol Acetate | insulin-like growth factor 1 | Mus musculus |