Pub. Date : 1999 Jun
PMID : 10362715
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The synthetic glucocorticoid dexamethasone has a major inhibitory effect on human surfactant protein A1 (SP-A1) and SP-A2 gene expression that occurs at both the transcriptional and posttranscriptional levels. | Dexamethasone | surfactant protein A1 | Homo sapiens |
| 2 | The synthetic glucocorticoid dexamethasone has a major inhibitory effect on human surfactant protein A1 (SP-A1) and SP-A2 gene expression that occurs at both the transcriptional and posttranscriptional levels. | Dexamethasone | surfactant protein A1 | Homo sapiens |
| 3 | Toward the identification of cis-acting elements that may be involved in the dexamethasone regulation of SP-A mRNA stability, chimeric chloramphenicol acetyltransferase (CAT) constructs that contained various portions of SP-A1 or SP-A2 cDNA in place of the native CAT 3"-untranslated region (UTR) were transiently transfected into the lung adenocarcinoma cell line NCI-H441. | Dexamethasone | surfactant protein A1 | Homo sapiens |
| 4 | Moreover, the inhibitory response seen with dexamethasone was greater for the 3"-UTR derived from the SP-A1 allele 6A3 than with the 3"-UTR derived from either the SP-A1 allele 6A2 or SP-A2 allele 1A0, indicating differential regulation between SP-A genes and/or alleles. | Dexamethasone | surfactant protein A1 | Homo sapiens |
| 5 | Moreover, the inhibitory response seen with dexamethasone was greater for the 3"-UTR derived from the SP-A1 allele 6A3 than with the 3"-UTR derived from either the SP-A1 allele 6A2 or SP-A2 allele 1A0, indicating differential regulation between SP-A genes and/or alleles. | Dexamethasone | surfactant protein A1 | Homo sapiens |
| 6 | Moreover, the inhibitory response seen with dexamethasone was greater for the 3"-UTR derived from the SP-A1 allele 6A3 than with the 3"-UTR derived from either the SP-A1 allele 6A2 or SP-A2 allele 1A0, indicating differential regulation between SP-A genes and/or alleles. | Dexamethasone | surfactant protein A1 | Homo sapiens |