Title : The protective effect of cyclosporine A on anti-Fas antibody-induced hepatitis in mice.

Pub. Date : 1999 Apr

PMID : 10361889






3 Functional Relationships(s)
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1 Anti-Fas antibody administration elevated CPP32-like protease activity at 3 hr in mouse liver, and this elevation of CPP32-like activity was inhibited by treatment with CsA. Cyclosporine caspase 3 Mus musculus
2 Anti-Fas antibody administration elevated CPP32-like protease activity at 3 hr in mouse liver, and this elevation of CPP32-like activity was inhibited by treatment with CsA. Cyclosporine caspase 3 Mus musculus
3 The present results show that CsA treatment inhibits the anti-Fas antibody-induced apoptotic process of hepatitis, at least in part, by affecting a reaction upstream of CPP32-like protease activation. Cyclosporine caspase 3 Mus musculus