Title : Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro.

Pub. Date : 1999 Jun

PMID : 10359564






2 Functional Relationships(s)
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1 We now report that reactive nitrogen species generated by the MPO-H2O2-NO2- system of monocytes convert LDL into a form (NO2-LDL) that is avidly taken up and degraded by macrophages, leading to massive cholesterol deposition and foam cell formation, essential steps in lesion development. Nitrogen Dioxide myeloperoxidase Homo sapiens
2 We now report that reactive nitrogen species generated by the MPO-H2O2-NO2- system of monocytes convert LDL into a form (NO2-LDL) that is avidly taken up and degraded by macrophages, leading to massive cholesterol deposition and foam cell formation, essential steps in lesion development. Nitrogen Dioxide myeloperoxidase Homo sapiens