Pub. Date : 1999 May
PMID : 10353733
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We investigated the response of the mitogen-activated protein kinases, extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun-N-terminal kinase 1 (JNK1), and p38, to cisplatin treatment in the ovarian carcinoma cell line SK-OV-3. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Cisplatin caused a late and prolonged induction in a dose-dependent manner of both ERK1/2 and JNK1 activity. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | ERK1/2 and JNK1 activities continued to increase in magnitude up to 24 h following initiation of cisplatin treatment. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Treatment with cycloheximide resulted in inhibition of cisplatin-induced ERK1/2 activation, demonstrating that ERK1/2 activity induced by cisplatin was dependent on de novo protein synthesis. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | Treatment with cycloheximide resulted in inhibition of cisplatin-induced ERK1/2 activation, demonstrating that ERK1/2 activity induced by cisplatin was dependent on de novo protein synthesis. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 6 | Treatment with cycloheximide resulted in inhibition of cisplatin-induced ERK1/2 activation, demonstrating that ERK1/2 activity induced by cisplatin was dependent on de novo protein synthesis. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 7 | Treatment with cycloheximide resulted in inhibition of cisplatin-induced ERK1/2 activation, demonstrating that ERK1/2 activity induced by cisplatin was dependent on de novo protein synthesis. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 8 | Furthermore, inhibition of cisplatin-induced ERK1/2 activity by PD 98059 caused enhanced cisplatin cytotoxicity. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 9 | Furthermore, inhibition of cisplatin-induced ERK1/2 activity by PD 98059 caused enhanced cisplatin cytotoxicity. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 10 | These observations indicate that ERK1/2 activation induced by cisplatin partially protects cells from cisplatin cytotoxicity. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |
| 11 | These observations indicate that ERK1/2 activation induced by cisplatin partially protects cells from cisplatin cytotoxicity. | Cisplatin | mitogen-activated protein kinase 3 | Homo sapiens |