Title : Binding of GM-CSF to adherent neutrophils activates phospholipase D.

Pub. Date : 1999 Mar

PMID : 10353694






3 Functional Relationships(s)
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1 However, GM-CSF did prime the cells for enhanced PA formation in the presence of a secondary stimulus (fMet-Leu-Phe or PAF). Protactinium colony stimulating factor 2 Homo sapiens
2 GM-CSF also caused a time-dependent stimulation of diacylglycerol formation in adherent, but not suspended, cells and elicited a time-dependent stimulation of phosphatidylethanol formation, with a concomitant decrease in the formation of PA only at early (< 7 min) times. Protactinium colony stimulating factor 2 Homo sapiens
3 Taken together the data indicate that GM-CSF rapidly activates PLD in adherent cells, which is responsible for the generation of PA. Protactinium colony stimulating factor 2 Homo sapiens