Pub. Date : 1999 Apr 30
PMID : 10350053
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We reported that protein kinase C (PKC) inhibitors increase the release of arachidonic acid induced by fluoroaluminate (AlF4-), an unspecific G-protein activator, in intact human platelets. | tetrafluoroaluminate | proline rich transmembrane protein 2 | Homo sapiens |
| 2 | We reported that protein kinase C (PKC) inhibitors increase the release of arachidonic acid induced by fluoroaluminate (AlF4-), an unspecific G-protein activator, in intact human platelets. | tetrafluoroaluminate | proline rich transmembrane protein 2 | Homo sapiens |
| 3 | Now we demonstrate that this effect is independent of the extracellular Ca2+ concentration and that AlF4(-)-induced release of AA is abolished by BAPTA, an intracellular Ca2+ chelator, even in the presence of GF 109203X, a specific and potent PKC inhibitor. | tetrafluoroaluminate | proline rich transmembrane protein 2 | Homo sapiens |
| 4 | These observations indicate that cPLA2 is responsible for the AlF4(-)-induced release of arachidonic acid by a mechanism that is down-regulated by PKC. | tetrafluoroaluminate | proline rich transmembrane protein 2 | Homo sapiens |