Title : The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.

Pub. Date : 1999 May

PMID : 10350003






3 Functional Relationships(s)
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1 RESULTS: A 5-h preincubation with glyceryl trinitrate (0.01-100 microM) led to complete inhibition of a subsequent cyclic GMP stimulation by glyceryl trinitrate but left the cyclic GMP response to SIN-1 unaltered. Nitroglycerin 5'-nucleotidase, cytosolic II Homo sapiens
2 RESULTS: A 5-h preincubation with glyceryl trinitrate (0.01-100 microM) led to complete inhibition of a subsequent cyclic GMP stimulation by glyceryl trinitrate but left the cyclic GMP response to SIN-1 unaltered. Nitroglycerin 5'-nucleotidase, cytosolic II Homo sapiens
3 RESULTS: A 5-h preincubation with glyceryl trinitrate (0.01-100 microM) led to complete inhibition of a subsequent cyclic GMP stimulation by glyceryl trinitrate but left the cyclic GMP response to SIN-1 unaltered. Nitroglycerin 5'-nucleotidase, cytosolic II Homo sapiens